“A clinical trial is any research study that prospectively assigns human participants or groups of humans to one or more health-related interventions to evaluate the effects on health outcomes.” (WHO)
Clinical trials offer an opportunity for patients to participate in scientific and industry research. In a clinical trial, participants receive specific interventions according to the research plan or protocol created by the investigators. These interventions may be medical products, such as drugs or devices, procedures, or changes to participants’ behavior, such as diet.
The following clinical trials are recruiting PSC patients. PSC Partners is collaborating with the pharmaceutical companies conducting these clinical trials by adding our patient perspective to the trial protocol and by sharing clinical-trial information with the PSC community.
Currently Recruiting in Canada
As of July 2023, there are three clinical trials currently recruiting PSC patients in Canada. There may be other research projects in which you may be involved. Before participating in a study, discuss the risks and potential benefits with your health care provider.
- Ipsen Pharmaceuticals: A Study to Assess Safety and Effectiveness of Elafibranor in Adult Participants With Primary Sclerosing Cholangitis. (ELMWOOD). Recruiting: For adult PSC patients. US, Canada and Spain study locations. ClinicalTrials.gov Identifier: NCT05627362.
- Mirum Pharmaceuticals: A Study to Evaluate Efficacy and Safety of an Investigational Drug Named Volixibat in Patients With Itching Caused by Primary Sclerosing Cholangitis (VISTAS), Recruiting: For adult PSC patients with pruritus. 26+ US and Canada study locations. ClinicalTrials.gov Identifier: NCT04663308.
- Pliant Therapeutics: Phase 2a Evaluation of Safety, Tolerability, and Pharmacokinetics of PLN-74809 in Patients With Primary Sclerosing Cholangitis (PSC), 10 study locations in Canada. For more information on this trial, visit Clinicaltrials.gov trial listing. Recruiting: For adult PSC patients. 50 Study locations in Australia, Canada, Europe, UK, and US. ClinicalTrials.gov Identifier: NCT04480840.
Additional Information on Clinical Trials
- Ask your hepatologist about any studies or clinical trials that you may be eligible to join.
- Please see the article in Volume 1, Issue 2 of the Loon Duct about clinical trials in Canada.
- Join the PSC Partners Patient registry and receive emails directly to your inbox about studies and clinical trials that you may be eligible to join.
- Visit the clinical trials page of the PSC Partners Patient Registry.
- Visit the US-based PSC Partners website content on clinical trials.
- Visit clinicaltrials.gov a searchable database of privately and publicly funded clinical studies conducted around the world.