PSC Partners Seeking a Cure Canada is an all-volunteer organization formed in 2015 to provide primary sclerosing cholangitis (PSC) patients and their caregivers education and support and to raise funds to research the origins and a cure for the disease. We are a public foundation and registered Canadian charity (#811905165 RR 0001).
PSC Partners Seeking a Cure Canada Board of Directors
- President: Mary Vyas
- Treasurer: Eve Jedrzejewska
- Secretary: Rachel Gomel
Basic Facts About PSC
PSC, primary sclerosing cholangitis, causes the bile ducts inside and outside the liver to become scarred, narrowed and eventually blocked. As more and more ducts are blocked, bile becomes trapped and damages the liver. The damage, if left unchecked, causes liver cell death, which leads to cirrhosis and may eventually require a liver transplant.
PSC is a rare disease that predominantly affects males ages 30-40 years old. About 43 percent do not have any symptoms when they are diagnosed. It is estimated that nearly 21 per 100,000 men and 6 per 100,000 women have the disease. PSC is often found in people with inflammatory bowel disease (IBD), most often ulcerative colitis (UC) and sometimes Crohn’s disease. Over 75 percent of PSC patients have ulcerative colitis. PSC is also associated with other autoimmune diseases.
Cause: No one knows what causes PSC. There may be genetic, autoimmune, and environmental origins. It isn’t contagious. PSC can’t be transmitted, through kissing, sexual activity, touching, or blood transfusion. There may be a genetic predisposition to PSC; however, most children of PSCers are healthy and unaffected.
There are medications and procedures that can help relieve some aspects of the disease and symptoms, but the only definitive treatment is a liver transplant. Still, many PSCers can live long and productive lives with the disease, and may never need a transplant.
Please visit the PSC Partners Seeking a Cure website for more information about PSC and for resources for patients, caregivers, family, and physicians.