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PSC Partners Seeking a Cure Canada
Toward a world with no PSC. Providing support & education to PSC patients & families. Raising funds f
PSC Partners Seeking a Cure, PSC Partners Canada and an inter-institution research team from Toronto are working together on pediatric PSC! Read all about it! We are very excited about the research and the opportunity to work with this team and disseminate the results of the work to the PSC patient community! Thank you Chan Zuckerberg Initiative for funding these rare inflammatory pediatric disease single cell projects!![]()
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www.uhn.ca/corporate/News/Pages/Patient_led_research_will_investigate_mechanisms_behind_rare_pedi...
"Can my donor be from outside of Canada?" Yes!![]()
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This question pops up a lot! Info available at this event sponsored by UHN, University Hospital Network, home of Ajmera transplant centre, in Toronto. Jan 26, registration required.Next Week: Join us for our Information for Living Donors Outside of Canada Webinar. ![]()
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For many potential transplant recipients, it can be difficult to find a living donor, especially if most of their family or friends live overseas, or outside of Canada. If you live outside of Canada, it is possible for you to donate a liver or kidney to a family member or friend who lives in Ontario.![]()
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This webinar will provide information about the process and supports available for potential living donors outside of Canada who are looking to donate to loved ones in Ontario.![]()
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Register Here: www.eventbrite.ca/e/information-for-living-donors-outside-of-canada-tickets-481704881267?aff=ebds...![]()
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#webinar #transplant #kidneydonor #kidneydonation #livingdonation #livingdonor #liverdonor #organdonation #livingorgandonor #outofcountrydonor #transplantwebinar #givelifeuhn
In Canada, how exception points for liver transplant are used is a bit of a mystery. This recent open-access article sheds light on current use of exception points by province. ![]()
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canlivj.utpjournals.press/doi/full/10.3138/canlivj-2022-0026
Exception points for liver transplantation: A Canadian review
canlivj.utpjournals.press
Abstract Background: Exception points (EP) for liver transplant (LT) allocation are used to account for mortality risk not reflected by scoring systems such as the Model for End-Stage Liver Disease wi...
Your support through donations and fundraising helps PSC Partners Canada fulfill our mission, including funding our PSC research grants program.![]()
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We're excited to announce the 2022 research grant that was recently awarded from PSC Partners Canada!![]()
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Targeting PSC Pathogenesis Using a Bifunctional Peptide, GP119, in the Mdr2-/- Mouse Model of PSC and Novel Multicellular Human-Derived 3D PSC Organoids ![]()
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Lead Investigators: ![]()
Heather Francis, PhD, FAASLD![]()
Gianfranco Alpini, PhD![]()
Indiana University![]()
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Lay summary: PSC is characterized by ductular reaction (expansion of bile ducts), inflammation and liver fibrosis. There are several models used to study PSC including animal models (Mdr2-/- mice) and liver organoids. Developing drugs for human use is critical to offer relief from the debilitating symptoms and PSC disease progression. The GP119 drug is approved for phase 1 clinical studies by Canada Health and our studies in both the mouse model of PSC and in human PSC-derived organoids will support the use of GP119 in a potential phase 2 clinical trial in PSC patients. The experiments proposed using human-derived 3D organoids will also allow us to examine the effects of GP119 in a liver microenvironment with potential for personalized medicine applicability.
Just over 24 hours left in the December matching grant! Visit www.pscpartners.ca/how-to-donate for ways to donate.